Cryo-EM structure of Lys05 bound GPR30-Gq complex structure
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xof
Q-score: 0.551
To Be Published
- Nanobody35 (Complex from Lama glama)
- Gpr30-gq (Complex from Homo sapiens)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Lys01 (440 Da, Ligand)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit q (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo-GPR30-Gq complex structure
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xog
Q-score: 0.462
To Be Published
- Gpr30-gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Water (18 Da, Ligand)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR30-Gq complex structure in the presence of E2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xoh
Q-score: 0.503
To Be Published
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr30-g1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xoi
Q-score: 0.522
To Be Published
- Gpr30-gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR30-Gq complex structure in the presence of G-1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xoj
Q-score: 0.522
To Be Published
- Gpr30-gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
5-HT1A-Gi in complex with compound (R)-IHCH-7179
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jt6
Q-score: 0.542
Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S
Cell (2024) 187 pp. 2194-2208.e22 [ Pubmed: 38552625 DOI: doi:10.1016/j.cell.2024.02.034 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- 1-(4-fluorophenyl)-4-[(7r)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one (377 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-ht1a-gi in complex with compound (r)-ihch-7179 (Complex from Homo sapiens)
Structure of cGAS in complex with SPSB3-ELOBC
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8okx
Q-score: 0.282
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ Pubmed: 38418882 DOI: doi:10.1038/s41586-024-07112-w ]
- Cgas-spsb3-elobc complex (Complex from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cyclic gmp-amp synthase (42 kDa, Protein from Homo sapiens)
- Spry domain-containing socs box protein 3 (27 kDa, Protein from Homo sapiens)
cGAS-Nucleosome in complex with SPSB3-ELOBC (composite structure)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ol1
Q-score: 0.4
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ Pubmed: 38418882 DOI: doi:10.1038/s41586-024-07112-w ]
- Histone h2a type 1-h (11 kDa, Protein from Homo sapiens)
- Cgas-spsb3-elobc complex (Complex from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Histone h2b type 1-h (10 kDa, Protein from Homo sapiens)
- Histone h2a type 1-j (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Histone h2b type 1-n (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Dna (145-mer) (44 kDa, DNA from Homo sapiens)
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Cyclic gmp-amp synthase (42 kDa, Protein from Homo sapiens)
- Spry domain-containing socs box protein 3 (27 kDa, Protein from Homo sapiens)
- Dna (145-mer) (44 kDa, DNA from Homo sapiens)
- Histone h3.2 (11 kDa, Protein from Homo sapiens)
Consensus refinement of cGAS/spsb3/EloBC/Nucleosome
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ Pubmed: 38418882 DOI: doi:10.1038/s41586-024-07112-w ]
human cGAS/spsb3/EloBC in complex with nucleosome (2:2)
Xu P, Liu Y, Liu C, Guey B, Li L, Melenec P, Ricci J, Ablasser A
Nature (2024) 627 pp. 873-879 [ Pubmed: 38418882 DOI: doi:10.1038/s41586-024-07112-w ]